Vijay Vedula


Tel(212) 853-2547

The Vedula group aims to advance clinical management of cardiovascular disease using computational modeling. We are developing novel computational techniques for performing patient-specific modeling of the cardiovascular system aimed at understanding the role of biomechanical factors in disease and development, device design, and `virtual' surgery planning. Computational modeling combined with machine learning and data-mining strategies provides unprecedented opportunities to not only examine acute response to treatment, but also predict and risk stratify patients susceptible to long-term remodeling and dysfunction.

The Vedula group is involved in developing multiscale-multiphysics models of the heart coupling cardiac electrophysiology, tissue mechanics, blood flow and valvular interactions, thereby creating an integrated heart model, that could be used to study a variety of cardiac and valvular diseases. A few applications that we are particularly interested in include, myocardial infarction and heart failure, valvular calcifications and repair, remodeling and dysfunction in congenital heart disease, aortic dissections and repair, cardiomyopathies, etc. We are actively collaborating with cardiologists and cardiothoracic surgeons for understanding the unmet clinical needs and thereby, provide engineering solutions with a goal to improve patient-management and provide a better quality of life. The techniques developed in our group could also find their utility in other traditional mechanical and aerospace engineering applications.


  • Columbia University, Mechanical Engineering, New York, NY Assistant Professor, Jan 2020 - present
  • Stanford University, Pediatrics, Stanford, CA Postdoctoral research associate, Jun 2015 - Dec 2019
  • UC San Diego, Mechanical and Aerospace Engineering, San Diego, CA Postdoctoral research associate, Feb 2015 - June 2015
  • Johns Hopkins University, Mechanical Engineering, Baltimore, MD Graduate research assistant, Aug 2010 - Feb 2015
  • GE India Technology Center, Bangalore, India Engineer, Dec 2009 - Aug 2010
  • Tridiagonal Solutions Pvt. Ltd., Pune, India CFD Engineer, Aug 2009 - Dec 2009


  • Department Scribe
  • Graduate Committee
  • American Society of Mechanical Engineers
  • American Physical Society
  • American Heart Association
  • Computer Methods in Biomechanics and Biomedical Engineering (CMBBE)
  • SimVascular Workshop & Training
  • SimVascular / SimCardio Workshop
  • NSF Fluids
  • Review Editor, Frontiers in Physiology
  • Annals of Biomedical Engineering
  • Biomechanics and Modeling in Mechanobiology
  • Biomedical Engineering / Biomedizinische Technik (BMT)
  • Cardiovascular Engineering and Technology (CVET)
  • Computers & Fluids
  • Computer Methods and Programs in Biomedicine (CMPB)
  • Fluids
  • Frontiers in Physiology
  • International Journal of Numerical Methods in Biomedical Engineering (IJNMBE)
  • Journal of Biomechanical Engineering (JBME)
  • Journal of Biomechanics
  • Journal of Computational Physics (JCP)
  • Journal of Fluid Mechanics (JFM)
  • Journal of the Mechanical Behavior of Biomedical Materials (JMBBM)


  • Theodore von K arm an Fellowship, RWTH Aachen University, 2018.
  • Child Health Research Institute Grant & Postdoctoral Fellowship, Stanford University Medical School, 2016-2017.
  • NSF-sponsored Young Investigator & Travel Award, 5th Engineering Frontiers Conference on Pediatrics and Congenital Heart Disease, Orlando, Florida 2016.
  • Gordon L. and Beatrice C. Bowles Fellowship, Johns Hopkins University, 2010.
  • I.I.T. Kanpur Academic Excellence Award, Indian Institute of Technology Kanpur, 2009.
  • General Electric (GE) Foundation Scholar-Leader 2008.


  • Zhu, C.y, Vedula, V.y, Parker, D., Wilson, N., Shadden, S. and Marsden, A., svFSI: A multiphysics package for integrated cardiac modeling, manuscript under preparation.
  • Motonaga, K.S.y, Vedula, V.y, Marsden, A., Chubb, H., Goodyer, W., Ceresnak, S., Feinstein, J. and Dubin, A., Is there a role for cardiac resynchronization therapy in pediatric idiopathic pulmonary hypertension?: A study of the electrical activation patterns utilizing 3D mapping, manuscript under preparation.
  • Li, R.L., Russ, J.B., Pierre-Louis, P., Kossar, A.P., Gibson, I., Paschalides, C., Herschmann, A.R., Ferrari, G., Bacha, E., Waisman, H., Vedula, V., Kysar, J.W. and Kalfa, D., In Vitro Proof of Concept of a First-Generation Growth-Accommodating Heart Valved Conduit for Pediatric Use. Biomaterials - manuscript under review.
  • Bazzi, M.S., Balouchzadeh, R., Pavey, S.N., Quirk, J.D., Yanagisawa, H., Vedula, V., Wagenseil, J.E. and Barocas, V.H., Experimental and mouse-specific computational models of the Fbln4SMKO mouse to identify potential biomarkers for ascending thoracic aortic aneurysm. Cardiovascular Engineering and Technology - manuscript under review.
  • Wang, H., Uhlmann, K., Vedula, V., Balzani, D. and Varnik, F., Fluid-structure interaction simulation of tissue degradation and its effects on intra-aneurysm hemodynamics. Biomechanics and Modeling in Mechanobiology - manuscript under review.
  • Chen, I.y, Vedula, V.y, Malik, S., Liang, T., Chung, K., Nguyen, P., Sayed, N., Tsao, P., Giacomini, J., Marsden, A. and Wu, J., Preoperative computed tomography angiography reveals lea et-specific c contribution to aortic stenosis in influenced by local coronary factors, Circulation: Cardiovascular Imaging - manuscript under review.
  • Marsden, A. L., Vedula, V., Tikenogullari, O., and Kuhl, E., "Towards patient-specific multi-physics modeling of cardiac function", 56th Annual Technical Meeting of the Society of Engineering Sciences (SES2019), St Louis MO, USA, Oct. 13-15, 2019.
  • Vedula, V., Liu, J., Tikenogullari, O., Kuhl, E., and Marsden, A. L., "A multiphysics model of cardiac function - methods and verification", 16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE2019), New York NY, USA, Aug. 14-16, 2019.
  • Hsu, J., Vedula, V., Baek, K. I., Chen, C., Ding, Y., Tintut, Y., Marsden, A., and Hsiai, T., "Contractile and hemodynamic forces promote cardiac valve development via Notch1b-mediated endothelial-to-mesenchymal transition", Circulation, 138(Suppl 1), A14393-A14393, 2018.
  • Vedula, V., and Marsden, A., "Patient specific modeling of intraventricular hemodynamics", 69th Meeting of the American Physical Society Division of Fluid Dynamics, Denver CO, USA, Nov. 19-21, 2017.
  • Lee, J., Vedula, V., Ding, Y., Chen, J., Marsden, A., and Hsiai, T., "Spatiotemporal variations in intracardiac shear stress differentially modulate trabeculation for developmental contractile function. Circulation, 136(Suppl 1), A19511-A19511, 2017.