Patient specific factors governing the success of trans-catheter aortic valves

Heart valve disease is a major component of heart disease in the western world and more so in the developing world. Although artificial heart valves have prolonged countless lives, critical challenges still remain due to issues surrounding durability, thromboembolic risks, operative risks, and high cost. The rapid adoption of trans-catheter valves has only magnified these issues which in order to be completely addressed require a truly multi-disciplinary and translational collaboration between engineering and medicine. In this talk, I will present our current efforts towards transforming the entire clinical pipeline and relevant guidelines from diagnosis, planning, delivery, and follow-up using patient specific factors. This will be illustrated through a series of experimental and computational studies aimed at revealing the complex interaction between trans-catheter aortic valves in patient-specific anatomies in the context of the development of adverse outcomes such as leaflet thrombosis, coronary obstruction and residual pressure gradients. Over the long term this research aims to bring precision medicine guidelines based planning and personalization of artificial heart valve replacement therapy.

Lakshmi Prasad Dasi, Ph.D., is an established researcher in the field of prosthetic heart valves, cardiovascular biomechanics, biomaterials, and devices. He is currently a tenure Professor of Biomedical Engineering, at Georgia Institute of Technology while holding the Rozelle Vanda Wesley Endowed Professorship as well as being the Associate Chair for Undergraduate Studies. He has held positions at
The Ohio State University, and Colorado State University previously. He is a Fellow of the American College of Cardiology (FACC) as well as Fellow of the American Institute for Medical and Biological Engineering (FAIMBE).

Prof. Dasi earned his Ph.D. from Georgia Institute of Technology in 2004 with a focus in fluid dynamics and turbulence. He trained as a postdoctoral fellow and research engineer under Prof. Ajit Yoganathan’s mentorship at Georgia Tech where he transformed his research focus to heart valves, devices, and cardiovascular biomechanics. In 2009, he established the Cardiovascular Biofluid Mechanics Lab (CBFL) as Assistant Professor at Colorado State University and moved to The Ohio State University in 2015 as his focus became more translational. Since 2020, his research at Georgia Tech focuses on tackling the complexity of: (a) heart valve biomechanics (native and prosthetic); (b) prosthetic heart valve engineering (conventional & trans-catheter); (c) structure-function relationships of the heart in health and disease at the embryonic, pediatric, as well as adult stages; and (d) turbulence and turbulent blood flow.

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